姓名: 易濤 Name: YI TAO,

職銜 Academic title
副教授 Associate Professor
照片 Photo

電郵 Email: yitao@mpu.edu.mo

辦公室電話 Tel: 3471 辦公室Office: 明德樓 (MENG TAK)-7/F, M707
地址Address:
 中國澳門高美士街
Rua de Luís Gonzaga Gomes, Macau, China

學歷 Academic qualifications
- 華中科技大學理學博士 (2008)
- 華中科技大學理學碩士 (2004)
- 第二軍醫大學理學學士 (1996)

個人簡介 Biography
Dr. Tao Yi had been doing research on new drugs in Wuhan general hospital for nearly a decade since 1996. He received his Ph.D. from the National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology in 2008. From 2008 to 2010, he was an associate professor at Southwest University (a key university under the direct leadership of the Ministry of Education of China, 211 Engineering University). From 2010 to 2014, he served as an assistant professor of State Key Laboratory of Quality Research in Chinese Medicine at Macau University of Science and Technology. Since August 2014, he has been a lecturer at Macao Polytechnic University.
He has obtained 2 new drug certificates and 3 provincial and ministerial scientific progress awards. As the first inventor, he has obtained 3 Chinese invention patents and 2 Australian innovation patents. He has published more than 40 papers. He edited and published 2 books. He as a PI has been awarded over 10 major research grants from agencies including Macao Science and Technology Development Fund (FDCT), Research Fund of Macao Polytechnic University, Research Program of Hubei Province and Natural Science Fund of Chongqing.
Positions
  • 2022 - Present, Associate Professor at Macao Polytechnic University;
  • 2014 - 2022, Lecturer at Macao Polytechnic University;
  • 2010 - 2014, Assistant Professor at State Key Laboratory of Quality Research in Chinese Medicine (Macao University of Science and Technology);
  • 2008 - 2010, Associate Professor at School of Pharmacy, Southwest University (directed by the Ministry of Education of China, 211 Engineering University);
  • 1996 - 2005, Pharmacist and Supervisor Pharmacist at Pharmacy Department of Wuhan General Hospital.
Teaching
  • Undergraduate Modules:
    • Pharmaceutics (2008-2010, School of Pharmacy, Southwest University);
    • Pharmacology, Pharmaceutical analysis, Pharmacokinetics (2014 - present, Macao Polytechnic University).
  • Postgraduate Modules:
    • Biopharmaceutics and Pharmacokinetics (2008 - 2010, School of Pharmacy, Southwest University);
    • Biopharmaceutics and Pharmacokinetics, Chinese Medicine Pharmaceutics (2010 - 2014, Macau University of Science and Technology).

出版 Publications

Selected publications

  1. Tao Yi, Jifen Zhang. Effects of Hydrophilic Carriers on Structural Transitions and in Vitro Properties of Solid Self-Microemulsifying Drug Delivery Systems. Pharmaceutics, 2019, 11(6), 267.
  2. Lu Xiao, Ying Liu, Tao Yi*. Development of a New Ex Vivo Lipolysis-Absorption Model for Nanoemulsions. Pharmaceutics,2019, 11(4), 164. (*Corresponding Author)
  3. Jifen Zhang, Jiao Zhang, Shuai Wang and Tao Yi*. Development of an Oral Compound Pickering Emulsion Composed of Nanocrystals of Poorly Soluble Ingredient and Volatile Oils from Traditional Chinese Medicine. Pharmaceutics, 2018, 10(4), 170. (*Corresponding Author)
  4. Yi, T.,Dandan Tang, Wang, F., Zhang Jiqiong, Zhang, J., Wang, J., Xu Xiaoyu, Zhang, J.F. Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies. Drug delivery, 2017; 24(1): 422–429.
  5. Yi, T., Liu, C., Zhang, J., Wang, F., Wang, J., Zhang, J.F. A new drug nanocrystal self-stabilized Pickering emulsion for oral delivery of silybin. European Journal of Pharmaceutical Sciences, Volume 96, 1 January 2017, Pages 420–427.
  6. Xiao, L., Yi, T.#, Chen, M., Lam, C.W.K., Zhou, H. A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP. European Journal of Pharmaceutical Sciences, volume 93, 10 Oct 2016, pp. 456 – 467. (#Equal first author)
  7. Lu Xiao, Tao Yi*, Ying Liu, Hua Zhou*. The in vitro lipolysis of lipid-based drug delivery systems: a newly identified relationship between drug release and liquid crystalline phase. BioMed Research International, vol. 2016, Article ID 2364317, 9 pages, 2016. doi:10.1155/2016/2364317. (*Corresponding Author)
  8. Liang Li, Tao Yi*, Christopher Wai-kei Lam. Inhibition of Human Efflux Transporter ABCC2 (MRP2) by Self-emulsifying Drug Delivery System: Influences of Concentration and Combination of Excipients. J Pharm Pharm Sci, 17(4) 447 - 460, 2014. (*Corresponding Author)
  9. Hui Zhou, Jiangling Wan, Lei Wu, Tao Yi*, Wei Liu, Huibi Xu, Xiangliang Yang. A new strategy for enhancing the oral bioavailability of drugs with poor water-solubility and low liposolubility based on phospholipid complex and supersaturated SEDDS. PLOS ONE. 2013.(*Corresponding Author)
  10. Liang Li, Tao Yi*, Christopher Waikei Lam. Interactions between Human Multidrug Resistance Related Protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). International Journal of Pharmaceutics. 2013, 447(1-2):192-198.　(*Corresponding Author)
  11. Liang Li, Tao Yi#, Christopher Waikei Lam. Effects of Spray-drying and Choice of Solid Carriers on Concentrations of Labrasol and Transcutol in Solid Self-microemulsifying Drug Delivery Systems. Molecules. 2013, 18: 545-560. (#Equal first author)
  12. Lu Xiao, Tao Yi*, Ying Liu. A new self-microemulsifying mouth dissolving film to improve the oral bioavailability of poorly water soluble drugs. Drug Development and Industrial Pharmacy, 2013, 39(9):1284-1290.(*Equal first author and Corresponding Author)
  13. Tao Yi, Jiangling Wan, Huibi Xu and Xiangliang Yang. A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics, 2008, 70(2): 439-444.
  14. Tao Yi, Jiangling Wan, Huibi Xu and Xiangliang Yang. Controlled poorly soluble drug release from solid self-microemulsifying formulations with high viscosity hydroxypropylmethylcellulose. European Journal of Pharmaceutical Sciences, 2008, 34(4-5): 274-280.
  15. Jifen Zhang, Yanhua Wang, Qingqing Li, Tao Yi*. The research progress of Pickering emulsion drug delivery systems. Acta Pharmaceutica Sinica, 2019, 54 (*Corresponding Author)
  16. Jifen Zhang, Chuan Liu, Jiao Zhang, Tao Yi*. Preparation and evaluation of silybin nanocrystallines self-stabilizing Pickering emulsion. Acta Pharmaceutica Sinica, 2016, 51 (5): 813−820. (*Corresponding Author)
  17. Lu Xiao, Tao Yi*. Mechanisms of hydroxypropyl methylcellulose for the precipitation inhibitor of supersaturatable self-emulsifying drug delivery systems. Acta Pharmaceutica Sinica, 2013,48(5):767-772 (*Corresponding Author)
  18. Hongqiao Li, Tao Yi*. Preparation and in vitro characterization of berberine hydrochloride self-emulsifying microsphere by membrane emulsification technology. Acta Pharmaceutica Sinica, 2013,48(4):554-559 (*Corresponding Author)
  19. Chuan Liu, Tao Yi*. Research progress of self-assembled beads drug delivery system prepared from cyclodextrins and oils. Acta Pharmaceutica Sinica, 2012, 47 (12): 1582−1586 (*Corresponding Author)
  20. Ying Liu, Tao Yi*, Di Huan, Lu Xiao, Jiku He. Establishment and evaluation of a dynamic in vitro intestinal absorption model of lipid formulations. Acta Pharmaceutica Sinica, 2011, 46(8):983-989 (*Corresponding Author)
  21. Hui Ou-yang, Tao Yi*, Qin Zheng, Feng Liu. Microcosmic mechanisms of amorphous indomethacin crystallization and the influence of nano-coating on crystallization. Acta Pharmaceutica Sinica, 2011, 46(6): 707-712 (*Corresponding Author)
  22. Di Huan, Tao Yi*, Ying Liu, Lu Xiao, Jikui He. Influence of silica on intestinal absorption of solid self-microemulsifying drug delivery systems. Acta Pharmaceutica Sinica, 2011, 46(4):466-471 (*Corresponding Author)
  23. Lu Xiao, Tao Yi*, Ying Liu, Di Huan, Jikui He. Optimization of novel self-microemulsifying mouth dissolving films by response surface methodology. Acta Pharmaceutica Sinica, 2011,46(5):586-591 (*Corresponding Author)

 

Books

  1. Modern Pharmacy Information Technology, edited by Ren Tong, Tao Yi, Yi Zhang, People's Medical Publishing House, 2003.
  2. Internet pharmacy, edited by Ren Tang, Yi Zhang, Tao Yi, People's Medical Publishing House, 2001.

 

Patents

  1. Tao Yi, Li Liang, Wai Kai Lam. Pharmaceutical compositions for treating cardiac and cerebral vascular diseases and their preparation (201210308893.7), authorizing publication No. CN102805751B.
  2. Tao Yi, Chuan Liu. Silybin nanocrystal self-stabilized Pickering emulsion and its preparation method (201410064969.5), authorizing publication No. CN103877021B.
  3. Tao Yi, lihua Tang, Liang Li. Scutellarin nanocrystal suspension and its preparation method (201210429487.6), authorizing publication No. CN103006556B.
  4. Tao Yi, Liang Li, Wai Kai Lam. A pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and method of manufacturing the same. Australian innovation patent, 2013101145.
  5. Tao Yi, Chuan Liu. A Pickering emulsion comprising nanocrystals of Silybin and a method of preparation thereof. Australian innovation patent, 2014100743.

 

New drug research

  • Acyclovir dispersible tablets (new drug certificate X19990224)
  • Oxaprozin dispersible tablets (new drug Certificate X20000540)
  • Lovastatin sustained release tablets and capsules
  • oleanolic acid nanocrystal suspensions

 

Research Grants

Ongoing projects

  • Science and Technology Development Fund of Macao Special Administrative Region: Research on drug nanocrystal self-stabilizing Pickering Emulsions of active components in Chinese Medicine (001/2016/A1, MOP 1,630,000)
  • Macao Polytechnic Institute research project: Research on New Nanomedicine Targeting Dermal Tissue for Androgenetic Alopecia Treatment (RP / ESS-01/2018, MOP 248,800)  

Completed Projects

  • Natural Science Fund of Chongqing: Molecular Pharmaceutical Research on Solid Self-Emulsifying Drug Delivery Systems (CSTC2009BB5106, CNY 30,000)
  • Chongqing University Excellent Achievements Transformation Project: Study on the solid Self-microemulsifying Drug Delivery System of Berberine (KJ08B06, CNY 60,000)
  • The Fundamental Research Funds for the Central Universities: Research on oral sustained and controlled release solid self-emulsifying drug delivery systems (XDJK2009C076, CNY 50,000)
  • Hubei Province Science and Technology Research Project: Development of Doxazosin Osmotic Pump Controlled Release Tablets (2005AA301B08, CNY 50,000)
  • Southwest University Ph.D. Fund: Research on Solid Self-microemulsifying Drug Delivery System for Traditional Chinese Medicine (SWUB2008032, CNY 50,000)
  • Traditional Chinese Medicine Research Project of Chongqing Municipal Health Bureau: Research on self-microemulsifying mouth dissolving films of Ginkgo biloba leaves extract (2010-2-135, CNY 40,000)
  • Science and Technology Development Fund of Macao Special Administrative Region:: Investigation on solid self-microemulsifying drug delivery systems of scutellarin (003/2011/A, MOP 481,300)
  • Science and Technology Development Fund of Macao Special Administrative Region: Investigation on oral self-emulsifying pulsatile drug delivery systems of berberine (051/2012/A, MOP 495,300)
  • Science and Technology Development Fund of Macao Special Administrative Region: Investigation on supersaturating lipid-based microcapsules to improve oral bioavailability of poorly water-soluble flavonoids (094/2012/A3, MOP 2,145,400)
  • Macau University of Science and Technology research project: Investigation on new nano drug delivery systems to improve oral bioavailability of BCS class IV drugs (NO.0269, MOP 99,000)
  • Macao Polytechnic Institute research project: Multifunctional and multimode gold nanostar-based nanocomposite of Chinese medicine active ingredients for cancer therapy (RP / ESS-06/2014, MOP 248,900)

 

Professional Contributions

  • Member of Chinese medicine preparation branch of China Association of Chinese Medicine
  • Young member of the editorial board of Acta Pharmaceutica Sinica 
  • Chinese licensed pharmacist

 

Awards

  • Second Prize of Science and Technology Progress Award of People's Liberation Army of China (2001): Research and application of hydrophilic swellable dispersible tablets (ranked 5th );
  • Third Prize of Science and Technology Progress Award of People's Liberation Army of China (2001): Research on Pharmacokinetic and pharmacodynamic interactions between propafenone enantiomers; (ranked 4th ) 
  • Third Prize of Science and Technology Progress Award of Hubei Province (2000): Research on Internet pharmacy work model and establishment of pharmacy website (ranked 2nd )

科研興趣 Research interests
Research Interests
  • Nanomedicine research, mainly on targeted drug delivery systems for cancer treatment, such as gold nanostars;
  • New formulation research on Traditional Chinese Medicine, mainly on new oral dosage forms of poorly water-soluble soluble APIs in Chinese Medicine, such as nanocrystal suspensions, nanocrystal self-stabilized Pickering emulsions, solid self-microemulsifying drug delivery systems, self-microemulsifying oral instant films and self-emulsifying microspheres.

最近兩年任教科目 Subjects taught in last two years
- 基礎化學 (GENERAL CHEMISTRY) 2023/2024
- 藥物化學 (MEDICINAL CHEMISTRY) 2023/2024
- 有機化學 (ORGANIC CHEMISTRY) 2023/2024
- 藥物分析 (PHARMACEUTICAL ANALYSIS) 2023/2024
- 藥劑學 (PHARMACEUTICS) 2023/2024
- 藥物動力學 (PHARMACOKINETICS) 2023/2024
- 藥理學I (PHARMACOLOGY I) 2023/2024
- 藥理學II (PHARMACOLOGY II) 2023/2024
- 專題習作I (THESIS I) 2023/2024
- 專題習作II (THESIS II) 2023/2024

研究人員檔案 Researcher Profile